A naturally occurring naphthoquinine; increases glucose uptake by adipocytes and inhibits PTEN activity; inhibits glycolysis in cancer cells by inhibiting tumor-specific pyruvate kinase M2; inhibits leukocyte migration

Shikonin – 5 mg

Brand:
Cayman
CAS:
517-89-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Shikonin is a naturally occurring naphthoquinine isolated from the dried root of L. erythrorhizon, an herb used in traditional Chinese medicine. It increases glucose uptake by adipocytes and myocytes and inhibits the activity of phosphatase and tensin homolog (PTEN; IC50 = 2.7 µM).{23514,23519} It inhibits glycolysis in cancer cells by inhibiting tumor-specific pyruvate kinase M2 (IC50 = 0.3 µM).{23515} Shikonin induces cell death consistent with necroptosis in MCF-7 and HEK293 cancer cell lines.{23516} It inhibits leukocyte migration, downregulates chemokine receptor expression, and inhibits HIV-1 replication at nanomolar concentrations.{23517} Shikonin exhibits anti-inflammatory activity, reducing joint swelling and cartilage destruction in a mouse model of collagen-induced arthritis.{23518}  

 

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Description

A naturally occurring naphthoquinine; increases glucose uptake by adipocytes and inhibits PTEN activity; inhibits glycolysis in cancer cells by inhibiting tumor-specific pyruvate kinase M2; inhibits leukocyte migration, downregulates chemokine receptor expression, and inhibits HIV-1 replication; reduces joint swelling and cartilage destruction in a mouse model of collagen-induced arthritis

Formal name: 5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione

Synonyms:  C.I. 75535|Isoarnebin 4|NSC 252844

Molecular weight: 288.3

CAS: 517-89-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Natural Products|Naphthoquinones||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer|Cell Death|Necroptosis||Research Area|Cancer|Cell Signaling||Research Area|Cancer|Metabolism||Research Area|Cell Biology|Cell Death|Necroptosis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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