A cyclohexenecarboxylic acid; an intermediate in the biosynthesis of aromatic amino acids in plants and microorganisms; a precursor in the synthesis of oseltamivir; decreases lipid droplet accumulation in HepG2 cells and 3T3-L1 adipocytes at 80 µM; increases the levels of phosphorylated AMPK and decreases the levels of MID1IP1 in HepG2 and 3T3-L1 adipocytes at 40 µM; decreases inflammation and demyelination in a mouse model of EAE at 50-200 mg/kg and reduces symptom progression at 100 mg/kg

Shikimic Acid – 1 g

Brand:
Cayman
CAS:
138-59-0
Storage:
-20
UN-No:
Non-Hazardous - /

Shikimic acid is a cyclohexenecarboxylic acid originally isolated from I. religiosum.{46308} It is an intermediate in the biosynthesis of aromatic amino acids in plants and microorganisms. Shikimic acid is also a precursor in the synthesis of oseltamivir (Item No. 16070).{46309} It decreases lipid droplet accumulation in HepG2 cells and 3T3-L1 adipocytes when used at a concentration of 80 µM, as well as increases the levels of phosphorylated AMPK and decreases the levels of MID1IP1 in HepG2 and 3T3-L1 adipocytes when used at 40 µM.{46310} Shikimic acid increases differentiation of oligodendrocyte precursor cells in vitro.{46311} It decreases inflammation and demyelination in a mouse model of experimental autoimmune encephalomyelitis (EAE) when administered at doses of 50-200 mg/kg and reduces symptom progression at a dose of 100 mg/kg.{46311} It also induces remyelination in a model of focal demyelination induced by L-α-lysophosphatidylcholine (LPC) in mouse dorsal spinal cord.  

 

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Description

A cyclohexenecarboxylic acid; an intermediate in the biosynthesis of aromatic amino acids in plants and microorganisms; a precursor in the synthesis of oseltamivir; decreases lipid droplet accumulation in HepG2 cells and 3T3-L1 adipocytes at 80 µM; increases the levels of phosphorylated AMPK and decreases the levels of MID1IP1 in HepG2 and 3T3-L1 adipocytes at 40 µM; decreases inflammation and demyelination in a mouse model of EAE at 50-200 mg/kg and reduces symptom progression at 100 mg/kg

Formal name: 3R,4S,5R-trihydroxy-1-cyclohexene-1-carboxylic acid

Synonyms:  ,L-Shikimic Acid|(–)-Shikimic Acid|NSC 59257

Molecular weight: 174.2

CAS: 138-59-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Lipid Biochemistry||Research Area|Neuroscience||Research Area|Plant Biology

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