An NPSR antagonist (IC50s = 22 and 23.8 nM for the NPSR Asn107 and NPSR Ile107 isoforms

SHA-68 – 25 mg

Brand:
Cayman
CAS:
847553-89-3
Storage:
-20
UN-No:
Non-Hazardous - /

SHA-68 is an antagonist of the neuropeptide S receptor (NPSR; IC50s = 22 and 23.8 nM for the NPSR Asn107 and NPSR Ile107 isoforms, respectively).{37267} It is selective for NPSR over a panel of 14 G protein-coupled receptors exhibiting no activity at a concentration of 10 μM. SHA-68 (50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing in mice. SHA-68 also reduces conditioned reinstatement of cocaine seeking in rats.{37268}  

 

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Description

An NPSR antagonist (IC50s = 22 and 23.8 nM for the NPSR Asn107 and NPSR Ile107 isoforms, respectively); selective for NPSR over a panel of 14 G protein-coupled receptors exhibiting no activity at a concentration of 10 μM; reduces NPS-induced horizontal activity and vertical rearing and climbing in mice when administered at a dose of 50 mg/kg; reduces conditioned reinstatement of cocaine seeking in rats

Formal name: N-[(4-fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide

Synonyms: 

Molecular weight: 445.5

CAS: 847553-89-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research

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