An inhibitor of the DNA methyltransferases DNMT1

SGI-1027 – 1 mg

Brand:
Cayman
CAS:
1020149-73-8
Storage:
-20
UN-No:
Non-Hazardous - /

SGI-1027 is an inhibitor of the DNA methyltransferases DNMT1, DNMT3A, and DNMT3B (IC50s = 12.5, 8, and 7.5 μM, respectively, with Poly(dI-dC) as the substrate).{20127} It has been shown to cause the degradation of DNMT1 and to reactivate silenced tumor suppressor genes by reducing CpG island hypermethylation.{20127}  

 

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SKU: 11165 - 1 mg Category:

Description

An inhibitor of the DNA methyltransferases DNMT1, DNMT3A, and DNMT3B (IC50s = 12.5, 8, and 7.5 μM, respectively, with Poly(dI-dC) as the substrate); reactivates silenced tumor suppressor genes by reducing CpG island hypermethylation

Formal name: N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)-benzamide

Synonyms:  DNA Methyltransferase Inhibitor II

Molecular weight: 461.5

CAS: 1020149-73-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|DNA/RNA Methylation

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