A potent allosteric inhibitor of PRMT3 (IC50 = 50 nM) with >100-fold selectivity over other methyltransferases and other non-epigenetic targets; avidly binds PRMT3 (Kd = 50 nM by isothermal titration calorimetry) and inhibits histone methylation in cells with an IC50 value below 1 µM

SGC707 – 50 mg

Brand:
Cayman
CAS:
1687736-54-4
Storage:
-20
UN-No:
Non-Hazardous - /

Protein arginine N-methyltransferase 3 (PRMT3, Item No. 11642) is a predominantly cytoplasmic enzyme that is constitutively expressed.{21260,20245} SGC707 is a potent allosteric inhibitor of PRMT3 (IC50 = 50 nM) with >100-fold selectivity over other methyltransferases and other non-epigenetic targets. Developed by the Structural Genomics Consortium (SGC), SGC707 avidly binds PRMT3 (Kd = 50 nM by isothermal titration calorimetry) and inhibits the methylation of histones in cells with an IC50 value below 1 µM.  

 

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Description

A potent allosteric inhibitor of PRMT3 (IC50 = 50 nM) with >100-fold selectivity over other methyltransferases and other non-epigenetic targets; avidly binds PRMT3 (Kd = 50 nM by isothermal titration calorimetry) and inhibits histone methylation in cells with an IC50 value below 1 µM

Formal name: N-6-isoquinolinyl-N’-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea

Synonyms: 

Molecular weight: 298.3

CAS: 1687736-54-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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