Inhibits PTEN activity (IC50 = 2 μM)

SF1670 – 1 mg

Brand:
Cayman
CAS:
345630-40-2
Storage:
-20
UN-No:
Non-Hazardous - /

Phosphatase and tensin homology on chromosome 10 (PTEN) functions as a key regulatory enzyme in many signal transduction pathways by dephosphorylating proteins and lipids including Akt and phosphatidylinositol 3,4,5-trisphosphate (PIP3). SF1670 specifically binds to the active site of PTEN inhibiting its activity with an IC50 value of 2 μM.{24903,14756} At nanomolar concentrations it increases cellular PIP3 levels, phosphorylation of Akt, and glucose uptake in adipocytes.{14756,24902} Pretreatment with SF1670 has been used to enhance PIP3 signaling in transplanted neutrophils, augmenting their function at sites of infection in neutropenic recipient mice.{24902}  

 

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Description

Inhibits PTEN activity (IC50 = 2 μM), increasing cellular PIP3 levels, phosphorylation of Akt, and glucose uptake in adipocytes; used to enhance PIP3 signaling in transplanted neutrophils

Formal name: N-(9,10-dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide

Synonyms: 

Molecular weight: 307.4

CAS: 345630-40-2

Purity: ≥98%

Formulation: A dark purple solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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