An angular pyranocoumarin with diverse biological activities; cytotoxic to P388 and HT-29 cells in vitro (EC50s = 8.66 and 9.94 μg/ml); reduces acetic acid-induced writhing in mice at 0.5

Seselin – 5 mg

Brand:
Cayman
CAS:
523-59-1
Storage:
-20
UN-No:
Non-Hazardous - /

Seselin is an angular pyranocoumarin that has been found in M. semecarpifolia and has diverse biological activities.{53386,53387,53388,53389} It is cytotoxic to P388 and HT-29 cells in vitro (EC50s = 8.66 and 9.94 μg/ml).{53386} Seselin (0.5, 4.5, and 40.5 mg/kg) reduces acetic acid-induced writhing in mice.{53387} It also reduces paw licking in the first and second phases of the formalin test in mice when administered 30 minutes prior to formalin. Seselin (3, 10, and 30 mg/kg) decreases serum levels of IL-1β, IL-6, and TNF-α in a mouse model of sepsis induced by cecal ligation and puncture and increases survival when administered at a dose of 30 mg/kg.{53388} It reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice (ED45 = 0.25 mg/ear).{53389}  

 

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SKU: 29930 - 5 mg Category:

Description

An angular pyranocoumarin with diverse biological activities; cytotoxic to P388 and HT-29 cells in vitro (EC50s = 8.66 and 9.94 μg/ml); reduces acetic acid-induced writhing in mice at 0.5, 4.5, and 40.5 mg/kg; reduces paw licking in the first and second phases of the formalin test in mice when administered 30 minutes prior to formalin; decreases serum levels of IL-1β, IL-6, and TNF-α in a mouse model of sepsis induced by cecal ligation and puncture at 3, 10, and 30 mg/kg and increases survival at 30 mg/kg; reduces TPA-induced ear edema in mice (ED45 = 0.25 mg/ear)

Formal name: 8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-2-one

Synonyms: 

Molecular weight: 228.2

CAS: 523-59-1

Purity: ≥95%

Formulation: A solid

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