A broad spectrum antifungal agent; fungistatic and fungicidal in vitro (MICs = 0.35 to 5.04 and 0.5 to 16 μg/ml

Sertaconazole (nitrate) – 50 mg

Brand:
Cayman
CAS:
99592-39-9
Storage:
-20
UN-No:
Non-Hazardous - /

Sertaconazole is a broad spectrum antifungal agent that is both fungistatic and fungicidal in vitro (MICs = 0.35 to 5.04 and 0.5 to 16 μg/ml, respectively).{41014} It inhibits ergosterol (Item No. 19850) synthesis (IC50 = 115 nM) and decreases intracellular ATP levels in a dose-dependent manner in C. albicans.{41015,41016} Topical application of sertaconazole (0.03 ml of a 2% formulation) reduced C. albicans cell numbers by 97.9% in a murine model of vaginal candidiasis.{41014} Formulations containing sertaconazole have been used to treat T. corporis dermal infections.{41017}  

 

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Description

A broad spectrum antifungal agent; fungistatic and fungicidal in vitro (MICs = 0.35 to 5.04 and 0.5 to 16 μg/ml, respectively); inhibits ergosterol synthesis (IC50 = 115 nM) and decreases intracellular ATP in a dose-dependent manner in C. albicans; topical application (0.03 ml of a 2% formulation) reduced C. albicans cell numbers by 97.9% in a murine model of vaginal candidiasis

Formal name: 1-[2-[(7-chlorobenzo[b]thien-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, mononitrate

Synonyms:  ,FI-7045

Molecular weight: 500.8

CAS: 99592-39-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals|Imidazoles||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Infectious Disease|Fungal Diseases|Ringworm

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