A potent antagonist of the TXA2 receptor

Seratrodast – 50 mg

Brand:
Cayman
CAS:
112665-43-7
Storage:
-20
UN-No:
Non-Hazardous - /

Seratrodast is a potent antagonist of the thromboxane A2 (TXA2) receptor (TP), blocking specific binding of U-46619 (Item No. 16450) to guinea pig platelets with an IC50 value of 7.4 nM and platelet aggregation induced by U-44069 (Item No. 16440) with an IC50 value of 350 nM.{26820,26819} It is metabolized, in liver microsomes, by cytochrome P450 (CYP) isoforms 3A and 2C9/10, with a minor contribution from CYP2C8 and CYP2C19.{26816} Seratrodast is commonly used to study the roles of the TP receptor in animal airways and in tissue samples.{26820,26817,26818,26815}  

 

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SKU: 9002014 - 50 mg Category:

Description

A potent antagonist of the TXA2 receptor, blocking specific binding of U-46619 to platelets with an IC50 value of 7.4 nM and platelet aggregation induced by U-44069 with an IC50 value of 350 nM; commonly used to study the roles of the TP receptor in animal airways and in tissue samples

Formal name: ζ-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-benzeneheptanoic acid

Synonyms:  A-73001|AA2414|ABT-001

Molecular weight: 354.4

CAS: 112665-43-7

Purity: ≥98%

Formulation: A crystalline solid

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