A potent and selective CB2 receptor agonist

SER-601 – 50 mg

Brand:
Cayman
CAS:
1048038-90-9
Storage:
-20
UN-No:
Non-Hazardous - /

SER-601 is a potent and selective peripheral cannabinoid (CB2) receptor agonist with 190-fold selectivity for CB2 over the central CB1 receptor (Kis = 6.3 and 1,220 nM, respectively).{20869,20870} At 3 mg/kg, SER-601 has analgesic effects in a formalin-induced nocifensive study in mice without cannabis-like behavioral effects due to its low affinity for the CB1 receptor.{20869,20870} SER-601 also has antidiabetic effects.{35108} Two to four week exposure to SER-601 ameliorates insulin resistance in vivo and increases insulin secretion and accumulation in pancreatic islets isolated from high-fat diet/streptozotocin (HFD/STZ)-induced diabetic mice.  

 

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SKU: 11743 - 50 mg Category:

Description

A potent and selective CB2 receptor agonist, with 190-fold selectivity for CB2 over the CB1 receptor (Kis = 6.3 and 1,220 nM, respectively); 3 mg/kg induces analgesia in a formalin-induced nocifensive study in mice without cannabis-like behavioral effects; ameliorates insulin resistance in vivo and increases insulin secretion and accumulation in pancreatic islets isolated from HFD/STZ-induced diabetic mice

Formal name: 1,4-dihydro-6-(1-methylethyl)-4-oxo-1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl-3-quinolinecarboxamide

Synonyms: 

Molecular weight: 434.6

CAS: 1048038-90-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors||Research Area|Neuroscience|Pain Research

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