A glycoside; inhibits H+/K+-ATPase activity in isolated rat stomach mucosa and increases levels of PGE2 in AGS gastric cells at 100 µM; increases the intestinal transport rate by 72.2% but has no effect on the gastric emptying rate in mice at 100 mg/kg; reduces lesion indices by 39.9 and 62.9% in HCl/ethanol-induced gastritis and indomethacin-induced gastric ulcers

Sennoside B – 25 mg

Brand:
Cayman
CAS:
128-57-4
Storage:
-20
UN-No:
Non-Hazardous - /

Sennoside B is a glycoside that has been found in C. acutifolia and has laxative and gastroprotective activities.{53043,43197} It inhibits H+/K+-ATPase activity in isolated rat stomach mucosa and increases levels of prostaglandin E2 (PGE2; Item No. 14010) in AGS gastric cells when used at a concentration of 100 µM.{43197} Sennoside B (100 mg/kg) increases the intestinal transport rate by 72.2% but has no effect on the gastric emptying rate in mice. It reduces lesion indices by 39.9 and 62.9% in HCl/ethanol-induced gastritis and indomethacin-induced gastric ulcers, respectively, in rats when administered at a dose of 100 mg/kg. Formulations containing sennoside B have been used in the treatment of constipation.  

 

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SKU: 28410 - 25 mg Category:

Description

A glycoside; inhibits H+/K+-ATPase activity in isolated rat stomach mucosa and increases levels of PGE2 in AGS gastric cells at 100 µM; increases the intestinal transport rate by 72.2% but has no effect on the gastric emptying rate in mice at 100 mg/kg; reduces lesion indices by 39.9 and 62.9% in HCl/ethanol-induced gastritis and indomethacin-induced gastric ulcers, respectively, in rats at 100 mg/kg

Formal name: (9R,9’S)-5,5′-bis(β-D-glucopyranosyloxy)-9,9′,10,10′-tetrahydro-4,4′-dihydroxy-10,10′-dioxo-[9,9′-bianthracene]-2,2′-dicarboxylic acid

Synonyms: 

Molecular weight: 862.7

CAS: 128-57-4

Purity: ≥98%

Formulation: A solid

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