A dianthrone glycoside with laxative and gastroprotective activities; increases the amplitude of distal colon contractions in circular and longitudinal muscle and decreases the amplitude of proximal colon contractions in circular muscle ex vivo in mice at 30 mg/kg; increases the gastric emptying rate and increases the intestinal transport rate of a charcoal meal in mice at 100 mg/kg; increases the concentration of PGE2 in AGS gastric cells in vitro; increases gastric juice pH and decreases gastric juice secretion volume and total acid output in pylorus-ligated rats at 100 mg/kg; reduces lesion indices by 43.1 and 36% in HCl/ethanol-induced gastritis and indomethacin-induced gastric ulcer rat models

Sennoside A – 25 mg

Brand:
Cayman
CAS:
81-27-6
Storage:
-20
UN-No:
Non-Hazardous - /

Sennoside A is a dianthrone glycoside with laxative and gastroprotective activities.{43196,43197} Ex vivo, sennoside A (30 mg/kg) increases the amplitude of distal colon contractions in circular and longitudinal muscle and decreases the amplitude of proximal colon contractions in circular muscle in mice.{43196} Sennoside A (100 mg/kg, oral) increases the gastric emptying rate by 71.1% compared to control and increases the intestinal transport rate of a charcoal meal from 61.2 to 81.1% in mice.{43197} It increases the concentration of prostaglandin E2 (PGE2; Item No. 14010) in AGS gastric cells in a dose-dependent manner in vitro. Intraduodenal administration of sennoside A (100 mg/kg) increases gastric juice pH and decreases gastric juice secretion volume and total acid output in pylorus-ligated rats. It also reduces lesion indices by 43.1 and 36% in HCl/ethanol-induced gastritis and indomethacin-induced gastric ulcer rat models, respectively, when administered at a dose of 100 mg/kg. Sennoside A is also a non-competitive inhibitor of bovine serum monoamine oxidase in vitro (IC50 = 17 µM).{43198} Formulations containing sennoside A have been used to treat constipation and to aid in evacuation of the bowel prior to surgery or invasive colonic or rectal examinations.  

 

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Description

A dianthrone glycoside with laxative and gastroprotective activities; increases the amplitude of distal colon contractions in circular and longitudinal muscle and decreases the amplitude of proximal colon contractions in circular muscle ex vivo in mice at 30 mg/kg; increases the gastric emptying rate and increases the intestinal transport rate of a charcoal meal in mice at 100 mg/kg; increases the concentration of PGE2 in AGS gastric cells in vitro; increases gastric juice pH and decreases gastric juice secretion volume and total acid output in pylorus-ligated rats at 100 mg/kg; reduces lesion indices by 43.1 and 36% in HCl/ethanol-induced gastritis and indomethacin-induced gastric ulcer rat models, respectively, at 100 mg/kg; a non-competitive inhibitor of bovine serum monoamine oxidase in vitro (IC50 = 17 µM)

Formal name: (9R,9’R)-5,5′-bis(β-D-glucopyranosyloxy)-9,9′,10,10′-tetrahydro-4,4′-dihydroxy-10,10′-dioxo-[9,9′-bianthracene]-2,2′-dicarboxylic acid

Synonyms:  NSC 112929

Molecular weight: 862.7

CAS: 81-27-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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