Description
A dianthrone glycoside with laxative and gastroprotective activities; increases the amplitude of distal colon contractions in circular and longitudinal muscle and decreases the amplitude of proximal colon contractions in circular muscle ex vivo in mice at 30 mg/kg; increases the gastric emptying rate and increases the intestinal transport rate of a charcoal meal in mice at 100 mg/kg; increases the concentration of PGE2 in AGS gastric cells in vitro; increases gastric juice pH and decreases gastric juice secretion volume and total acid output in pylorus-ligated rats at 100 mg/kg; reduces lesion indices by 43.1 and 36% in HCl/ethanol-induced gastritis and indomethacin-induced gastric ulcer rat models, respectively, at 100 mg/kg; a non-competitive inhibitor of bovine serum monoamine oxidase in vitro (IC50 = 17 µM)
Formal name: (9R,9’R)-5,5′-bis(β-D-glucopyranosyloxy)-9,9′,10,10′-tetrahydro-4,4′-dihydroxy-10,10′-dioxo-[9,9′-bianthracene]-2,2′-dicarboxylic acid
Synonyms: NSC 112929
Molecular weight: 862.7
CAS: 81-27-6
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway
