A phthalide with cytoprotective and antiproliferative activities; protects against cell injury induced by corticosterone in PC12 cells at 0.125-0.5 mg/ml; reduces corticosterone-induced apoptosis at 0.5 mg/ml in PC12 cells; inhibits cell proliferation of HT-29 colon cancer (IC50 = 54.17 µM) but not non-cancerous human CCD-18Co colon cells (IC50 = 109.11 µM)

Senkyunolide A – 5 mg

Brand:
Cayman
CAS:
63038-10-8
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Senkyunolide A is a phthalide originally isolated from celery seed essential oil that has cytoprotective and antiproliferative activities.{42461} It protects against cell injury induced by corticosterone in PC12 cells in a time-dependent manner when used at concentrations ranging from 0.125 to 0.5 mg/ml and reduces corticosterone-induced apoptosis at a concentration of 0.5 mg/ml.{42462} It also reverses increases in protein levels of phosphatase 2A (PP2A) and α-synuclein and reverses decreases in the phosphorylated forms of PP2A and α-synuclein. Senkyunolide A inhibits cell proliferation of HT-29 colon cancer (IC50 = 54.17 µM) but not non-cancerous human CCD-18Co colon cells (IC50 = 109.11 µM).{42463}  

 

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SKU: 25199 - 5 mg Category:

Description

A phthalide with cytoprotective and antiproliferative activities; protects against cell injury induced by corticosterone in PC12 cells at 0.125-0.5 mg/ml; reduces corticosterone-induced apoptosis at 0.5 mg/ml in PC12 cells; inhibits cell proliferation of HT-29 colon cancer (IC50 = 54.17 µM) but not non-cancerous human CCD-18Co colon cells (IC50 = 109.11 µM)

Formal name: (3S)-3-butyl-4,5-dihydro-1(3H)-isobenzofuranone

Synonyms:  (–)-Sedanenolide|(S)-Sedanenolide

Molecular weight: 192.3

CAS: 63038-10-8

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Natural Products||Research Area|Cancer||Research Area|Neuroscience

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