An inhibitor of IKCa1/KCa3.1 channels; inhibits A23187-induced rubidium efflux from and dehydration of isolated human RBCs (IC50s = 11 and 30 nM

Senicapoc – 100 mg

Brand:
Cayman
CAS:
289656-45-7
Storage:
-20
UN-No:
Non-Hazardous - /

Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels.{46700,46701} It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (Item No. 11016; IC50s = 11 and 30 nM, respectively).{46700} Senicapoc (10 mg/kg twice per day) reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease. It inhibits IL-2, IFN-γ, IL-12, and IL-17A production in CD3+ T cells stimulated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) and ionomycin (Item Nos. 10004974 | 11932) when used at a concentration of 1 μM.{46702} Senicapoc (100 mg/kg) increases the paw withdrawal threshold in a rat model of chronic constriction injury (CCI) of the sciatic nerve.{46701}  

 

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SKU: 29679 - 100 mg Category:

Description

An inhibitor of IKCa1/KCa3.1 channels; inhibits A23187-induced rubidium efflux from and dehydration of isolated human RBCs (IC50s = 11 and 30 nM, respectively); reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease at 10 mg/kg twice per day; inhibits production of IL-2, IFN-γ, IL-12, and IL-17A in PMA- and ionomycin-stimulated CD3+ T cells at 1 μM; increases the paw withdrawal threshold in a rat model of CCI of the sciatic nerve at 100 mg/kg

Formal name: 4-fluoro-α-(4-fluorophenyl)-α-phenyl-benzeneacetamide

Synonyms:  ICA-17043

Molecular weight: 323.3

CAS: 289656-45-7

Purity: ≥98%

Formulation: A solid

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