An alkaloid with diverse biological activities; induces autophagy and decreases viability of Huh7.5 cells in a concentration-dependent manner; cytotoxic to HepG2 cells (IC20 = 0.66 mM); dietary administration induces sex-linked recessive lethality in male Drosophila; increases the activity of epoxide hydrase and glutathione-S-transferase and decreases activity of cytochrome P450 and aminopyrine demethylase in rat liver at 80 mg/kg

Seneciphylline – 5 mg

Brand:
Cayman
CAS:
480-81-9
Storage:
-20
UN-No:
De Minimis - 1544 / 6.1

Seneciphylline is an alkaloid that has been found F. japonicum and has diverse biological activites.{36920,36921,36922,36923} It induces autophagy and decreases viability of Huh7.5 cells in a concentration-dependent manner.{36920} Seneciphylline is also cytotoxic to HepG2 cells (IC20 = 0.66 mM).{36921} Dietary administration of seneciphylline induces sex-linked recessive lethality in male Drosophila.{36922} Seneciphylline (80 mg/kg) increases the activity of epoxide hydrase and glutathione-S-transferase and decreases activity of cytochrome P450 and aminopyrine demethylase in rat liver.{36923}  

 

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SKU: 25146 - 5 mg Category:

Description

An alkaloid with diverse biological activities; induces autophagy and decreases viability of Huh7.5 cells in a concentration-dependent manner; cytotoxic to HepG2 cells (IC20 = 0.66 mM); dietary administration induces sex-linked recessive lethality in male Drosophila; increases the activity of epoxide hydrase and glutathione-S-transferase and decreases activity of cytochrome P450 and aminopyrine demethylase in rat liver at 80 mg/kg

Formal name: (3Z,6R,14aR,14bR)-3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-methyl-5-methylene-[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione

Synonyms:  NSC 30622

Molecular weight: 333.4

CAS: 480-81-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Toxicology|Cell Health & Viability||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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