A class III antiarrhythmic agent; prolongs electrically stimulated APD and increases ERP in isolated guinea pig left atria; decreases spontaneous sinoatrial beating rates and induces ERP prolongation of the atrioventricular node in isolated perfused canine hearts; increases ERP

Sematilide (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
101526-62-9
Storage:
-20
UN-No:
Non-Hazardous - /

Sematilide is a class III antiarrhythmic agent and an analog of sotalol (Item No. 16136).{42876} It prolongs electrically stimulated action potential duration (APD) and increases the effective refractory period (ERP) in isolated guinea pig left atria. Sematilide decreases spontaneous sinoatrial beating rates and induces ERP prolongation of the atrioventricular node in isolated perfused canine hearts.{42877} In situ, sematilide (1 mg/kg) increases ERP, prolonging cardiac refractoriness, in open-chest dog hearts. Sematilide (0.3-6 mg/kg) inhibits arrhythmias induced by programmed electrical stimulation (PES), but not coronary ligation and reperfusion, two-stage coronary ligation, adrenaline, or digitalis, in dogs.{42878} Formulations containing sematilide have been used in the treatment of arrhythmias.  

 

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Description

A class III antiarrhythmic agent; prolongs electrically stimulated APD and increases ERP in isolated guinea pig left atria; decreases spontaneous sinoatrial beating rates and induces ERP prolongation of the atrioventricular node in isolated perfused canine hearts; increases ERP, prolonging cardiac refractoriness, in situ in open-chest dog hearts at 1 mg/kg; inhibits PES-induced arrhythmias in dogs,

Formal name: N-[2-(diethylamino)ethyl]-4-[(methylsulfonyl)amino]-benzamide, monohydrochloride

Synonyms:  CK-1752A

Molecular weight: 349.9

CAS: 101526-62-9

Purity: ≥98%

Formulation: A crystalline solid

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