A potent inhibitor of γ-secretase that blocks the production of Aβ38

Semagacestat – 1 mg

Brand:
Cayman
CAS:
425386-60-3
Storage:
-20
UN-No:
Non-Hazardous - /

Semagacestat is a potent inhibitor of γ-secretase that blocks the production of Aβ38, Aβ40, and Aβ42 with IC50 values of 12.0, 12.1, and 10.9 nM, respectively.{27630,27426} It also blocks Notch signaling (IC50 = 14.1 nM).{27426} Semagacestat modulates γ-secretase activity in vivo, altering Aβ levels in brain, cerebrospinal fluids, and plasma in a dose-dependent fashion.{27630,27426} Although semagacestat does not improve cognitive status in humans, it is useful as a pan γ-secretase inhibitor for research purposes.{27426,27631}  

 

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Description

A potent inhibitor of γ-secretase that blocks the production of Aβ38, Aβ40, and Aβ42 with IC50 values of 12.0, 12.1, and 10.9 nM, respectively; also blocks Notch signaling (IC50 = 14.1 nM); modulates γ-secretase activity in vivo, altering Aβ levels in brain, cerebrospinal fluids, and plasma in a dose-dependent fashion

Formal name: (2S)-2-hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]-butanamide

Synonyms:  LY450139

Molecular weight: 361.4

CAS: 425386-60-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Cell Signaling|Notch Signaling||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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