An orally bioavailable inhibitor ASK1 inhibitor (IC50 = 3.2 nM); a formulation containing selonsertib showed antifibrotic activity in a Phase II clinical trial; other clinical trials are ongoing

Selonsertib – 5 mg

Brand:
Cayman
CAS:
1448428-04-3
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1; IC50 = 3.2 nM), which is involved in a variety of conditions, including fibrosis, oxidative stress, and inflammation, among others.{34693} A formulation containing selonsertib showed antifibrotic activity in a Phase II clinical trial. Clinical trials are ongoing for other conditions, including severe alcoholic hepatitis and nonalcoholic steatohepatitis.  

 

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Description

An orally bioavailable inhibitor ASK1 inhibitor (IC50 = 3.2 nM); a formulation containing selonsertib showed antifibrotic activity in a Phase II clinical trial; other clinical trials are ongoing

Formal name: 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-benzamide

Synonyms:  GS-4977|GS-4997

Molecular weight: 445.5

CAS: 1448428-04-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH

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