A natural phthalide that induces the expression of GST and reduces chemical-induced carcinogenesis in mice; inhibits COX-1 and -2 at 250 pg/ml and blocks topoisomerase-I and-II activity at 100 µg/ml

Sedanolide – 50 mg

Brand:
Cayman
CAS:
6415-59-4
Storage:
-20
UN-No:
Non-Hazardous - /

Sedanolide is a natural phthalide first isolated from seed oil of the Umbelliferae family, including celery. It induces the expression of glutathione S-transferase and reduces chemical-induced carcinogenesis in mice.{28317} Sedanolide inhibits cyclooxygenases-1 and -2 at 250 pg/ml and blocks topoisomerase-I and-II activity at 100 µg/ml.{28315} It is mosquitocidal, nematicidal, and antifungal but shows no cytotoxicity against normal mammalian cells.{28314,28316}  

 

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Description

A natural phthalide that induces the expression of GST and reduces chemical-induced carcinogenesis in mice; inhibits COX-1 and -2 at 250 pg/ml and blocks topoisomerase-I and-II activity at 100 µg/ml

Formal name: 3-butyl-3a,4,5,6-tetrahydro-1(3H)-isobenzofuranone

Synonyms: 

Molecular weight: 194.3

CAS: 6415-59-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Infectious Disease|Fungal Diseases||Research Area|Infectious Disease|Parasitic Diseases

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