A neuropeptide hormone; binds to rat SCT-R (Ki = 3.3 nM) and increases intracellular cAMP (EC50 = 1 nM) in COS cells expressing rat SCT-R; dose-dependently increases the volume of pancreatic secretion and inhibits gastrin I-induced gastric acid secretion in rats (100 pmol/kg per hour)

Secretin (rat) – 1 mg

Brand:
Cayman
CAS:
121028-49-7
Storage:
-20
UN-No:
Non-Hazardous - /

Secretin is a neuropeptide hormone that regulates secretion from the stomach, pancreas, and liver.{38733,38734} It binds to the rat secretin receptor (SCT-R; Ki = 3.3 nM) and increases intracellular cAMP (EC50 = 1 nM) in COS cells expressing rat SCT-R.{38735} It also increases SCT-R phosphorylation 7.2-fold at a concentration of 0.1 μM. Secretin dose-dependently increases the volume of pancreatic secretion and inhibits gastric acid secretion induced by gastrin I (Item No. 24457) in rats when administered at a dose of 100 pmol/kg per hour.{38736}  

 

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SKU: 24561 - 1 mg Category:

Description

A neuropeptide hormone; binds to rat SCT-R (Ki = 3.3 nM) and increases intracellular cAMP (EC50 = 1 nM) in COS cells expressing rat SCT-R; dose-dependently increases the volume of pancreatic secretion and inhibits gastrin I-induced gastric acid secretion in rats (100 pmol/kg per hour)

Formal name:

Synonyms: 

Molecular weight: 3,027.40

CAS: 121028-49-7

Purity: ≥95%

Formulation: A lyophilized powder

Product Type|Biochemicals|Peptides|Peptide Hormones||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Neuroscience|Neuroendocrinology

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