A lignan with diverse biological activities; scavenges DPPH radicals (IC50 = 78.9 μg/ml) in a cell-free assay; dose-dependently inhibits the growth of SW480 human colon cancer cells; dietary administration reduces the number of proliferating tumor cells in an MCF-7 human breast cancer mouse xenograft model in the presence of circulating estrogen; increases insulin and decreases glucose serum levels in rats with streptozotocin-induced diabetes at 20 mg/kg; decreases infarct size in rats with myocardial infarction induced by permanent occlusion of the left anterior descending coronary artery at a 20 mg/kg per day

Secoisolariciresinol Diglucoside – 50 mg

Brand:
Cayman
CAS:
158932-33-3
Storage:
-20
UN-No:
Non-Hazardous - /

Secoisolariciresinol diglucoside (SDG) is a lignan that has been found in flaxseed with antioxidant, antiproliferative, antidiabetic, and cardioprotective biological activities.{41788,41789,41790,41791,41792,41793} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals (IC50 = 78.9 μg/ml) in a cell-free assay and dose-dependently inhibits the growth of SW480 human colon cancer cells in vitro.{41789,41790} Dietary administration of SDG reduces the number of proliferating tumor cells in an MCF-7 human breast cancer mouse xenograft model in the presence of circulating estrogen.{41791} It also increases insulin and decreases glucose serum levels in rats with diabetes induced by streptozotocin (Item No. 13104) when administered at a dose of 20 mg/kg.{41792} SDG (20 mg/kg per day) decreases infarct size in rats with myocardial infarction induced by permanent occlusion of the left anterior descending coronary artery.{41793}  

 

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Description

A lignan with diverse biological activities; scavenges DPPH radicals (IC50 = 78.9 μg/ml) in a cell-free assay; dose-dependently inhibits the growth of SW480 human colon cancer cells; dietary administration reduces the number of proliferating tumor cells in an MCF-7 human breast cancer mouse xenograft model in the presence of circulating estrogen; increases insulin and decreases glucose serum levels in rats with streptozotocin-induced diabetes at 20 mg/kg; decreases infarct size in rats with myocardial infarction induced by permanent occlusion of the left anterior descending coronary artery at a 20 mg/kg per day

Formal name: (2R,3R)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]-1,4-butanediyl bis-β-D-glucopyranoside

Synonyms:  SDG

Molecular weight: 686.7

CAS: 158932-33-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Lignans||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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