A selective inhibitor of cytohesins

SecinH3 – 25 mg

Brand:
Cayman
CAS:
853625-60-2
Storage:
-20
UN-No:
Non-Hazardous - /

Cytohesins are small guanine nucleotide exchange factors (GEFs) that stimulate adenosine diphosphate ribosylation factors (Arfs), GTPases which control signal transduction along various intracellular pathways.{25737} SecinH3 is a selective inhibitor of cytohesins, blocking human, mouse, and Drosophila cytohesins with IC50 values of 2.4 to 5.6 µM.{14565} It binds the Sec7 domain of these small Arf-GEFs but does not bind Sec7 domains of larger Arf-GEFs.{25739} In human liver carcinoma HepG2 cells, SecinH3 prevents cytohesin-dependent insulin signaling.{14565} In mice, SecinH3 produces hepatic insulin resistance.{14565} Inhibition of the cytohesin GEF from Drosophila, Steppke, blocks insulin signaling and interferes with development.{25736} SecinH3 is useful for studying the diverse roles of cytohesins, including the regulation of receptor-mediated cancer cell proliferation.{25738}  

 

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SKU: 10009570 - 25 mg Category:

Description

A selective inhibitor of cytohesins, blocking human, mouse, and Drosophila cytohesins with IC50 values of 2.4 to 5.6 µM; prevents cytohesin-dependent insulin signaling in HepG2 cells; produces hepatic insulin resistance in mice

Formal name: N-[4-[5-(1,3-benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)-acetamide

Synonyms: 

Molecular weight: 460.5

CAS: 853625-60-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer||Research Area|Cell Biology|Cell Signaling|GTPases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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