A selective inhibitor of the Na+/Ca2+ exchanger (IC50s = 5

SEA0400 – 10 mg

Brand:
Cayman
CAS:
223104-29-8
Storage:
-20
UN-No:
Non-Hazardous - /

SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger (IC50s = 5, 8.3, and 33 nM for inhibiting Na+-dependent Ca2+ uptake in rat astrocyte, microglia, and cortical neuron cell lines, respectively).{31853} It is reported to prevent dopaminergic neurotoxicity in an MPTP mouse model of Parkinson’s disease and to attenuate reperfusion injury in both in vitro and in vivo cerebral ischemic models.{31854,31852}  

 

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Description

A selective inhibitor of the Na+/Ca2+ exchanger (IC50s = 5, 8.3, and 33 nM for inhibiting Na+-dependent Ca2+ uptake in rat astrocyte, microglia, and cortical neuron cell lines, respectively)

Formal name: 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxy-benzenamine

Synonyms: 

Molecular weight: 371.4

CAS: 223104-29-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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