A hybrid of selenium and an NSAID that has been shown to reduce the viability of different cancer cell lines

Se-Aspirin – 50 mg

Brand:
Cayman
CAS:
1850293-95-6
Storage:
-20
UN-No:
Non-Hazardous - /

Se-Aspirin is a hybrid of selenium and a nonsteroidal anti-inflammatory drug that has been shown to reduce the viability of different cancer cell lines, particularly colorectal cancer (CRC) cells (IC50 = 3.4 µM).{31298} It can inhibit the cell cycle in G1 and G2/M phases and induce apoptosis by activating caspase 3/7 and PARP cleavage.{31298} Long-term exposure to Se-Aspirin is reported to cause an increase in intracellular reactive oxygen species levels in CRC cells.{31298}  

 

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Description

A hybrid of selenium and an NSAID that has been shown to reduce the viability of different cancer cell lines, particularly colorectal cancer (CRC) cells (IC50 = 3.4 µM); inhibits the cell cycle in G1 and G2/M phases and induces apoptosis by activating caspase 3/7 and PARP cleavage

Formal name: selenocyanic acid, 2-[[2-(acetyloxy)benzoyl]amino]ethyl ester

Synonyms:  Selenium-acetylsalicylic Acid

Molecular weight: 311.2

CAS: 1850293-95-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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