A selective inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM); has no inhibitory effect against a panel of other kinases when tested in vitro at 50 μM; orally active

SD 169 – 10 mg

Brand:
Cayman
CAS:
1670-87-7
Storage:
-20
UN-No:
Non-Hazardous - /

SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM).{22220} It has no inhibitory effect against a panel of other kinases, including p38γ MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 μM.{22220} SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg.{22220} In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis.{22220} SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage.{22221}  

 

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Description

A selective inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM); has no inhibitory effect against a panel of other kinases when tested in vitro at 50 μM; orally active, significantly reducing p38 MAP kinase expression in T cells of NOD mice when delivered in chow at 600 mg/kg

Formal name: 1H-indole-5-carboxamide

Synonyms:  5-Carbamoylindole

Molecular weight: 160.2

CAS: 1670-87-7

Purity: ≥97%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|p38 MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|p38 MAPK Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Neuroscience

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