A JAK2 inhibitor; inhibits autophosphorylation of recombinant JAK2 at 30 and 100 μM; decreases levels of phosphorylated JAK2

SD-1029 – 5 mg

Brand:
Cayman
CAS:
118372-34-2
Storage:
-20
UN-No:
Non-Hazardous - /

SD-1029 is a Janus kinase 2 (JAK2) inhibitor.{48790,48791} It inhibits autophosphorylation of recombinant JAK2 when used at concentrations of 30 and 100 μM and decreases levels of phosphorylated JAK2, but not JAK1 or Src, in MDA-MB-468 and paclitaxel-resistant OVCAR8TR cells when used at a concentration of 10 μM.{48790} SD-1029 (10 μM) decreases levels of phosphorylated STAT3 in MDA-MB-468, MDA-BM-435, OVCAR8TR, and SKOV3TR cells and inhibits IL-6-induced nuclear translocation of STAT3 in BHK-21 and U2OS cells.{48790} It decreases the viability of and increases levels of cleaved caspase-3 in SNU-387, SNU-398, HepG2, and Huh7 hepatocellular carcinoma cells when used at a concentration of 10 μM.{48792} SD-1029 (100 and 1,000 nM) inhibits hepatitis A virus replication in GL37 cells.{48791}  

 

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Description

A JAK2 inhibitor; inhibits autophosphorylation of recombinant JAK2 at 30 and 100 μM; decreases levels of phosphorylated JAK2, but not JAK1 or Src, in MDA-MB-468 and OVCAR8TR cells at 10 μM; decreases levels of phosphorylated STAT3 in MDA-MB-468, MDA-BM-435, OVCAR8TR, and SKOV3TR cells and inhibits IL-6-induced nuclear translocation of STAT3 in BHK-21 and U2OS cells at 10 μM; decreases the viability of and increases levels of cleaved caspase-3 in SNU-387, SNU-398, HepG2, and Huh7 hepatocellular carcinoma cells at 10 μM; inhibits hepatitis A virus replication in GL37 cells at 100 and 1,000 nM

Formal name: 9-(3,4-dichlorophenyl)-2,7-bis[(dimethylamino)methyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione, dihydrobromide

Synonyms:  JAK2 Inhibitor III|Janus-Associated Kinase 2 Inhibitor III

Molecular weight: 639.3

CAS: 118372-34-2

Purity: ≥80% (mixture of isomers)

Formulation: A solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Kinase Inhibitors|JAK Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cancer|Transcription Factors|STATs||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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