Description
A flavone with diverse biological activities; inhibits proliferation of PC-9 and H1975 NSCLC cells and induces apoptosis and autophagy at 160 µM; reduces tumor growth in an H1975 mouse xenograft model at 30 and 60 mg/kg per day; decreases serum total cholesterol and LDL-cholesterol and increases HDL-cholesterol in a high-fat diet-induced mouse model of NAFLD at 25 and 50 mg/kg; decreases hepatic MDA, GOT, GPT activity, increases CAT and T-AOC activity, and increases the hepatic expression of PPARγ, PGC-1α, and Nrf2 in a mouse model of NAFLD; prevents deficits in spatial and novel object memory in rats in the Y maze and novel object recognition test, respectively at 5, 25, and 50 mg/kg per day
Formal name: 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, β-D-glucopyranosiduronic acid
Synonyms: Scutellarein 7-O-β-D-glucuronide
Molecular weight: 462.4
CAS: 27740-01-8
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Lipid Biochemistry||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Catalase
