A flavone; has antioxidant activity in a TRAP assay at 1 μg/ml; inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the SARS coronavirus helicase nsP13 (IC50s = 12 and 0.86 μM

Scutellarein – 1 mg

Brand:
Cayman
CAS:
529-53-3
Storage:
-20
UN-No:
Non-Hazardous - /

Scutellarein is a flavone that has been isolated from S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities.{37603,37604,37605,37606,37607,37608} It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml.{37604} Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC50s = 12 and 0.86 μM, respectively).{37605,37606} It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM.{37607} In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.{37608}  

 

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SKU: 24977 - 1 mg Category:

Description

A flavone; has antioxidant activity in a TRAP assay at 1 μg/ml; inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the SARS coronavirus helicase nsP13 (IC50s = 12 and 0.86 μM, respectively); decreases LPS-induced NO release and iNOS and TNF-α mRNA expression in RAW 264.7 macrophages at 50 μM; decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model at 0.5 μg/g

Formal name: 5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Synonyms:  6-Hydroxyapigenin

Molecular weight: 286.2

CAS: 529-53-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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