A metabolite of scopolamine; binds to muscarinic acetylcholine receptors (IC50 = 3 µM); selective for muscarinic acetylcholine receptors over nicotinic acetylcholine receptors (IC50 = >500 µM); reduces hyperphagia induced by loxapine and chlorpromazine in C. elegans without affecting basal feeding; improves the blood-brain barrier permeability of chlorambucil when conjugated to chlorambucil

Scopine (hydrochloride) – 500 mg

Brand:
Cayman
CAS:
85700-55-6
Storage:
-20
UN-No:
Non-Hazardous - /

Scopine is a metabolite of the muscarinic antagonist scopolamine.{43932} Scopine binds to muscarinic acetylcholine receptors with an IC50 value of 3 µM and is selective for muscarinic acetylcholine receptors over nicotinic acetylcholine receptors (IC50 = >500 µM).{43933} It reduces hyperphagia induced by the antipsychotics loxapine (Item No. 20760) and chlorpromazine (Item No. 16129) in C. elegans without affecting basal feeding.{43934} When conjugated to chlorambucil, scopine improves the blood-brain barrier permeability of chlorambucil (Item No. 23744).{43935}  

 

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Description

A metabolite of scopolamine; binds to muscarinic acetylcholine receptors (IC50 = 3 µM); selective for muscarinic acetylcholine receptors over nicotinic acetylcholine receptors (IC50 = >500 µM); reduces hyperphagia induced by loxapine and chlorpromazine in C. elegans without affecting basal feeding; improves the blood-brain barrier permeability of chlorambucil when conjugated to chlorambucil

Formal name: (1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol, monohydrochloride

Synonyms: 

Molecular weight: 191.7

CAS: 85700-55-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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