A coumarin with diverse biological activities; inhibits angiotensin II-induced ECM remodeling and cell proliferation and reduces levels of collagen I and fibronectin in isolated primary neonatal rat cardiac fibroblasts from 1-10 µM; suppresses PDGF-BB-induced RASMC migration and wound healing in a scratch assay; reduces vascular neointima formation in a rat model of carotid artery balloon injury at 3.5 mg/kg; reduces hepatocyte apoptosis

Scoparone – 250 mg

Brand:
Cayman
CAS:
120-08-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Scoparone is a coumarin that has been found in A. capillaris and has diverse biological activities.{56223,56224,56226,56227,56225} It inhibits angiotensin II-induced extracellular matrix (ECM) remodeling and cell proliferation and reduces levels of collagen I and fibronectin in isolated primary neonatal rat cardiac fibroblasts when used at concentrations ranging from 1 to 10 µM.{56223} Scoparone suppresses PDGF-BB-induced rat aortic smooth muscle cell (RASMC) migration and wound healing in a scratch assay.{56224} In vivo, scoparone (3.5 mg/kg) reduces vascular neointima formation in a rat model of carotid artery balloon injury. Scoparone (80 mg/kg) reduces hepatocyte apoptosis, liver fibrosis, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and hepatic triglyceride levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine- and choline-deficient (MCD) diet.{56226} It reduces ulcer lesion area in a rat model of HCl- and ethanol-induced gastric ulcers.{56227} Scoparone also inhibits passive cutaneous anaphylaxis in rats.{56225}  

 

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Description

A coumarin with diverse biological activities; inhibits angiotensin II-induced ECM remodeling and cell proliferation and reduces levels of collagen I and fibronectin in isolated primary neonatal rat cardiac fibroblasts from 1-10 µM; suppresses PDGF-BB-induced RASMC migration and wound healing in a scratch assay; reduces vascular neointima formation in a rat model of carotid artery balloon injury at 3.5 mg/kg; reduces hepatocyte apoptosis, liver fibrosis, serum levels of ALT and AST, and hepatic triglyceride levels in a mouse model of MCD-induced NASH; reduces ulcer lesion area in a rat model of HCl- and ethanol-induced gastric ulcers; inhibits passive cutaneous anaphylaxis in rats

Formal name: 6,7-dimethoxy-2H-1-benzopyran-2-one

Synonyms:  6,7-Dimethoxycoumarin|6,7-Dimethylesculetin|Aesculetin dimethyl ether|Escoparone

Molecular weight: 206.2

CAS: 120-08-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Coumarins||Research Area|Cardiovascular System|Heart||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Gastric Disease|Peptic Ulcers

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