A sesquiterpene lactone with diverse biological activities; inhibits mycelial growth in the phytopathogenic fungi B. cinerea

Sclareolide – 50 mg

Brand:
Cayman
CAS:
564-20-5
Storage:
-20
UN-No:
Non-Hazardous - /

Sclareolide is a sesquiterpene lactone that has been found in Salvia and has diverse biological activities.{57254,57255,57257,57258} It inhibits mycelial growth in the phytopathogenic fungi B. cinerea, F. coeruleum, C. lunata, F. graminearum, and A. brassicae by 33.93, 67.14, 27.04, 46.22, and 32.48%, respectively, when used at a concentration of 100 μg/ml.{57255} Sclareolide is an Ebola virus entry inhibitor that reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with Ebola virus glycoprotein (EC50 = 8 μM).{57257} It inhibits nitric oxide production in LPS-stimulated BV-2 cells (IC50 = 20.3 μM).{57258} Sclareolide (5, 10, and 20 μM) enhances gemcitabine-induced cell death in gemcitabine-resistant PANC-1 and AsPC-1 human pancreatic cancer cells.{57254}  

 

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SKU: 31371 - 50 mg Category:

Description

A sesquiterpene lactone with diverse biological activities; inhibits mycelial growth in the phytopathogenic fungi B. cinerea, F. coeruleum, C. lunata, F. graminearum, and A. brassicae by 33.93, 67.14, 27.04, 46.22, and 32.48%, respectively, at 100 μg/ml; reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with Ebola virus glycoprotein (EC50 = 8 μM); inhibits nitric oxide production in LPS-stimulated BV-2 cells (IC50 = 20.3 μM); enhances gemcitabine-induced cell death in gemcitabine-resistant PANC-1 and AsPC-1 human pancreatic cancer cells at 5, 10, and 20 μM

Formal name: (3aR,5aS,9aS,9bR)-decahydro-3a,6,6,9a-tetramethyl-naphtho[2,1-b]furan-2(1H)-one

Synonyms:  (+)-Sclareolide|(R)-(+)-Sclareolide|Norambreinolide

Molecular weight: 250.4

CAS: 564-20-5

Purity: ≥98%

Formulation: A crystalline solid

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