Description
A diterpene with diverse biological activities; active against A. naeslundii, P. gingivalis, and P. anaerobius bacteria (MICs = 12.5, 6.2, and 3.1 μg/ml, respectively); inhibits LPS-induces increases in NO production and COX-2 and iNOS protein levels in RAW 264.7 macrophages at 5 and 10 μg/ml; reduces λ-carrageenan-induced hind paw edema in mice at 10 mg/kg; inhibits the growth of HCT116 cells (GI50 = 34 μM); induces apoptosis and halts the cell cycle at the G1 phase in HCT116 cells at 100 μM; reduces tumor growth in an HCT116 mouse xenograft model at 275 mg/kg, i.p., encapsulated in liposomes
Formal name: (αR,1R,2R,4aS,8aS)-α-ethenyldecahydro-2-hydroxy-α,2,5,5,8a-pentamethyl-1-naphthalenepropanol
Synonyms: (–)-Sclareol
Molecular weight: 308.5
CAS: 515-03-7
Purity: ≥98%
Formulation: A crystalline solid
