A dibenzocyclooctadiene with diverse biological activities; completely inhibits anti-CD3- and anti-CD28-induced release of IL-2

Schizandrin B – 5 mg

Brand:
Cayman
CAS:
61281-37-6
Storage:
-20
UN-No:
Non-Hazardous - /

Schizandrin B is a dibenzocyclooctadiene that has been found in F. schisandrae and S. chinensis with diverse biological activities.{42179,42180,42181} Schizandrin B (50 μM) completely inhibits anti-CD3- and anti-CD28-induced release of the cytokines IL-2, IL-3, IL-4, IL-6, and IFN-γ in T cells.{42182} In A549 adenocarcinoma cells, schizandrin B (1-30 μM) dose-dependently reduces cell survival and UV-induced phosphorylation of p53 and checkpoint kinase 1 (Chk1).{42179} Schizandrin B reduces kinase activity of the serine/threonine-protein kinase ATR with an IC50 value of 7.25 μM for the recombinant enzyme. In vivo, schizandrin B (25-100 mg/kg, p.o.) dose-dependently inhibits lipid peroxidation, formation of DNA strand breaks, and NADPH oxidase-dependent oxygen production induced by doxorubicin (Item No. 15007) in mouse heart.{42180} It also reduces the expression of p53, 3-nitrotyrosine, phosphorylated p38 MAPK and MAPKAPK-2, and matrix metalloproteinase-2 (MMP-2) and MMP-9. Schizandrin B (1 or 2 mmol/kg per day, p.o.) pretreatment reduces tert-butylhydroperoxide-induced mortality and malondialdehyde formation and increases glutathione (GSH) levels and Se-glutathione peroxidase (GSH-Px) activity in brain in mice.{42181}  

 

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SKU: 24968 - 5 mg Category:

Description

A dibenzocyclooctadiene with diverse biological activities; completely inhibits anti-CD3- and anti-CD28-induced release of IL-2, IL-3, IL-4, IL-6, and IFN-γ in T cells at 50 μM; reduces cell survival and UV-induced phosphorylation of p53 and Chk1 from 1-30 μM; reduces ATR kinase activity (IC50 = 7.25 μM); inhibits doxorubicin-induced lipid peroxidation, formation of DNA strand breaks, and NADPH oxidase-dependent oxygen production in mouse heart from 25-100 mg/kg; reduces the expression of p53, 3-nitrotyrosine, phosphorylated p38 MAPK and MAPKAPK-2, and MMP-2 and MMP-9; reduces tert-butylhydroperoxide-induced mortality and malondialdehyde formation and increases GSH levels and GSH-Px activity in mouse brain. ,

Formal name: (6R,7S,13aR)-rel-5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-benzo[3,4]cycloocta[1,2-f][1,3]benzodioxole

Synonyms:  Wuweizisu B

Molecular weight: 400.5

CAS: 61281-37-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Neuroscience||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|DNA/RNA Oxidative Damage||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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