Description
A dibenzocyclooctadiene with diverse biological activities; completely inhibits anti-CD3- and anti-CD28-induced release of IL-2, IL-3, IL-4, IL-6, and IFN-γ in T cells at 50 μM; reduces cell survival and UV-induced phosphorylation of p53 and Chk1 from 1-30 μM; reduces ATR kinase activity (IC50 = 7.25 μM); inhibits doxorubicin-induced lipid peroxidation, formation of DNA strand breaks, and NADPH oxidase-dependent oxygen production in mouse heart from 25-100 mg/kg; reduces the expression of p53, 3-nitrotyrosine, phosphorylated p38 MAPK and MAPKAPK-2, and MMP-2 and MMP-9; reduces tert-butylhydroperoxide-induced mortality and malondialdehyde formation and increases GSH levels and GSH-Px activity in mouse brain. ,
Formal name: (6R,7S,13aR)-rel-5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-benzo[3,4]cycloocta[1,2-f][1,3]benzodioxole
Synonyms: Wuweizisu B
Molecular weight: 400.5
CAS: 61281-37-6
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Neuroscience||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|DNA/RNA Oxidative Damage||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione
