A lignan with diverse biological activities; induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells at 100 μM; prevents glutamate-induced cytotoxicity

Schizandrin – 250 mg

Brand:
Cayman
CAS:
7432-28-2
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Schizandrin is a dibenzocyclooctadiene lignan and a major component of S. chinensis and has diverse biological activities.{48362,48363,48364,48365,48366} It induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM.{48362} Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells.{48363} It reduces apoptosis induced by cisplatin (Item No. 13119) in HK-2 human kidney cells.{48364} In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats.{48365} It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.{48366}  

 

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SKU: 27211 - 250 mg Category:

Description

A lignan with diverse biological activities; induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells at 100 μM; prevents glutamate-induced cytotoxicity, inhibits production of NO and ROS, and preserves the mitochondrial membrane potential in isolated rat cortical cells at 10 and 100 μM; reduces cisplatin-induced apoptosis in HK-2 cells; reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats at 1 and 10 mg/kg; enhances oxotremorine-induced tremors in mice; reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy at 10 mg/kg

Formal name: (6S,7S,12aR)-5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-dibenzo[a,c]cycloocten-6-ol

Synonyms:  (+)-Schizandrin|Schizandrol A

Molecular weight: 432.5

CAS: 7432-28-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Lignans||Research Area|Cancer|Cell Cycle|G1||Research Area|Immunology & Inflammation|Allergy||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neuroprotection

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