A lignan; inhibits formation of AGEs in vitro; decreases escape latency in the Morris water maze and increases spontaneous alternation in the Y-maze in a mouse model of Alzheimer's disease induced by amyloid-β (1-42) at 0.1 mg/kg; increases glial expression of GLP-1 and decreases immobility time in the FST in mice; increases spontaneous alternation in the Y-maze in a mouse model of stress-induced short-term learning impairment induced by the FST

Schisantherin B – 25 mg

Brand:
Cayman
CAS:
58546-55-7
Storage:
-20
UN-No:
Non-Hazardous - /

Schisantherin B (STB) is a lignan originally isolated from S. sphenanthera fruit.{47351} It inhibits formation of advanced glycation end products (AGEs) in vitro.{47352} STB (0.1 mg/kg) decreases escape latency in the Morris water maze and increases spontaneous alternation in the Y-maze in a mouse model of Alzheimer’s disease induced by amyloid-β (1-42) (Item No. 20574).{47353} It increases glial expression of glutamate transporter 1 (GLP-1) and decreases immobility time in the forced swim test (FST) in mice, indicating antidepressant-like activity.{47354} STB also increases spontaneous alternation in the Y-maze in a mouse model of stress-induced short-term learning impairment induced by the FST.  

 

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Description

A lignan; inhibits formation of AGEs in vitro; decreases escape latency in the Morris water maze and increases spontaneous alternation in the Y-maze in a mouse model of Alzheimer’s disease induced by amyloid-β (1-42) at 0.1 mg/kg; increases glial expression of GLP-1 and decreases immobility time in the FST in mice; increases spontaneous alternation in the Y-maze in a mouse model of stress-induced short-term learning impairment induced by the FST

Formal name: (2Z)-2-methyl-2-butenoic acid, (5S,6S,7S,13aS)-5,6,7,8-tetrahydro-6-hydroxy-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-5-yl ester

Synonyms:  Gomisin B|Schizantherin B|Wuweizi ester B

Molecular weight: 514.6

CAS: 58546-55-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Lignans||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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