A lignan with hepatoprotective activity; increases the expression of the PXR target genes Cyp3a11

Schisandrol B – 25 mg

Brand:
Cayman
CAS:
58546-54-6
Storage:
-20
UN-No:
Non-Hazardous - /

Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity.{43493} It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells.{43494} It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen (Item No. 10024).{43496,43495}  

 

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SKU: 25149 - 25 mg Category:

Description

A lignan with hepatoprotective activity; increases the expression of the PXR target genes Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells; protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice; decreases mortality in a mouse model of cholestasis at 100 mg/kg twice per day

Formal name: (6S,7S,13aR)-5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-6-ol

Synonyms:  Besigomsin|Gomisin A|Wuweizichun B

Molecular weight: 416.5

CAS: 58546-54-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Lignans||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Toxicology|Drug Metabolism

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