A lignan with diverse biological activities; decreases viability of U937 cells induces cell cycle arrest at the G1 phase; decreases hydrogen peroxide-induced cell death and production of ROS in C2C12 skeletal muscle cells from 5-20 μM; decreases levels of MMP-2

Schisandrin C – 10 mg

Brand:
Cayman
CAS:
61301-33-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Schisandrin C is a lignan originally isolated from Schizandrae that has diverse biological activities.{30124,35736,47582,47583,47584} It decreases viability of U937 cells in a concentration-dependent manner and induces cell cycle arrest at the G1 phase when used at a concentration of 100 μM.{35736} Schisandrin C (5-20 μM) decreases hydrogen peroxide-induced cell death and production of reactive oxygen species (ROS) in C2C12 skeletal muscle cells.{47582} It also decreases levels of matrix metalloproteinase-2 (MMP-2), MMP-9, COX-2, VCAM-1, IL-1β, and TNF-α in hydrogen peroxide-stimulated C2C12 cells. Schisandrin C decreases lipoteichoic acid-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), TNF-α, IL-1β, and IL-6 in mouse primary microglia.{47583} In vivo, schisandrin C (200 mg/kg) decreases serum alanine amino transferase (ALT) and aspartate amino transferase (AST) activity, increases hepatic mitochondrial and total glutathione (GSH) levels, and reduces liver injury in a mouse model of acetaminophen-induced liver injury partially via inhibition of the cytochrome P450 (CYP) isoforms CYP2E1, CYP1A2, and CYP3A11.{47584}  

 

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Description

A lignan with diverse biological activities; decreases viability of U937 cells induces cell cycle arrest at the G1 phase; decreases hydrogen peroxide-induced cell death and production of ROS in C2C12 skeletal muscle cells from 5-20 μM; decreases levels of MMP-2, MMP-9, COX-2, VCAM-1, IL-1β, and TNF-α in hydrogen peroxide-stimulated C2C12 cells; decreases lipoteichoic acid-induced production of NO, PGE2, TNF-α, IL-1β, and IL-6 in mouse primary microglia; decreases serum ALT and AST activity, increases hepatic mitochondrial and total GSH levels, and reduces liver injury in a mouse model of acetaminophen-induced liver injury

Formal name: (6R,7S,13aS)-5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-cycloocta[1,2-f:3,4-f’]bis[1,3]benzodioxole

Synonyms:  Schizandrin C|Wuweizisu C

Molecular weight: 384.4

CAS: 61301-33-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Lignans||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Cancer|Cell Cycle|G1||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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