Description
A lignan with diverse biological activities; binds to adiponectin receptor 2 (IC50 = 3.2 µM); reduces LPS-induced production of NO, IL-6, and TNF-α and apoptosis in primary mouse microglial cells at 10, 20, and 50 µM; reverses P-glycoprotein-mediated doxorubicin resistance in MCF-7/dox cells at 20 µM; reverses Aβ42-induced short-term and spatial memory deficits, as well as decreases in cerebral SOD and GPX activities in a mouse model of Alzheimer’s disease at 4, 12, and 36 mg/kg
Formal name: (6R,7S,12aR)-5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-dibenzo[a,c]cyclooctene
Synonyms: Deoxyschizandrin|Wuweizisu A
Molecular weight: 416.5
CAS: 61281-38-7
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Lignans||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cancer|Multidrug Resistance||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Neuroprotection||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase
