A functionally selective inhibitor of Chk1 (Kd = 2 nM; IC50 = 3 nM); interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double-strand DNA breaks and cell death in tumor cells

SCH 900776 – 1 mg

Brand:
Cayman
CAS:
891494-63-6
Storage:
-20
UN-No:
Non-Hazardous - /

Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. SCH 900776 is a functionally selective inhibitor of Chk1 (Kd = 2 nM; IC50 = 3 nM).{29242} In comparison, 18-fold and 500-fold higher concentrations of this compound are required to inhibit CDK2 and Chk2.{29242} At 5-50 mg/kg, SCH 900776 dose-dependently interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double-strand DNA breaks and cell death in tumor cells.{29242}  

 

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Description

A functionally selective inhibitor of Chk1 (Kd = 2 nM; IC50 = 3 nM); interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double-strand DNA breaks and cell death in tumor cells

Formal name: 6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinyl-pyrazolo[1,5-a]pyrimidin-7-amine

Synonyms:  MK-8776

Molecular weight: 376.3

CAS: 891494-63-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Checkpoint Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling||Research Area|Cancer|DNA Damage and Repair

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