A non-peptide antagonist of PAR1; blocks binding of haTRAP (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or α-thrombin (IC50 = 0.3 and 3 µM

SCH 79797 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
1216720-69-2
Storage:
-20
UN-No:
Non-Hazardous - /

SCH 79797 is a non-peptide antagonist of proteinase-activated receptor 1 (PAR1).{23247} It blocks binding of the high affinity thrombin receptor-activating peptide (haTRAP) (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or α-thrombin (IC50 = 0.3 and 3 µM, respectively).{23246} SCH 79797 has no activity against PAR2, PAR4, or other receptors involved in platelet activation.{23246} It also blocks PAR1 activation on vascular smooth muscle cells and endothelial cells.{23246,23245}  

 

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Description

A non-peptide antagonist of PAR1; blocks binding of haTRAP (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or α-thrombin (IC50 = 0.3 and 3 µM, respectively); has no activity against PAR2, PAR4, or other receptors involved in platelet activation

Formal name: N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine, monohydrochloride

Synonyms: 

Molecular weight: 444.4

CAS: 1216720-69-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area

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