A dopamine D1 receptor antagonist (Ki = 5 nM); selective for D1 over D2-4 receptors (Kis = 3

SCH 39166 (hydrobromide) – 5 mg

Brand:
Cayman
CAS:
1227675-51-5
Storage:
-20
UN-No:
Non-Hazardous - /

SCH 39166 is a dopamine D1 receptor antagonist (Ki = 5 nM).{39925} It is selective for D1 over D2-4 receptors (Kis = 3,751, >1,000, and 5,934 nM, respectively), however, it also binds to D5 receptors (Ki = 4.4 nM). SCH 39166 inhibits food intake in a dose-dependent manner in rats (ED50 = 0.84 mg/kg).{39926} It reduces ethanol intake in Sardinian alcohol-preferring rats and sucrose intake in water-deprived and water-sated rats without affecting food or total fluid intake.{39927} SCH 39166 also suppresses cocaine-induced arrhythmias in anesthetized dogs.{39928}  

 

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SKU: 25331 - 5 mg Category:

Description

A dopamine D1 receptor antagonist (Ki = 5 nM); selective for D1 over D2-4 receptors (Kis = 3,751, >1,000, and 5,934 nM, respectively); binds to D5 receptors (Ki = 4.4 nM); inhibits food intake in a dose-dependent manner in rats (ED50 = 0.84 mg/kg); reduces ethanol intake in Sardinian alcohol-preferring rats and sucrose intake in water-deprived and water-sated rats without affecting food or total fluid intake; suppresses cocaine-induced arrhythmias in anesthetized dogs,

Formal name: 11-chloro-7-methyl-6,6αS,7,8,9,13βR-hexahydro-5H-benzo[d]naphtho[2,1-β]azepin-12-ol, monohydrobromide

Synonyms: 

Molecular weight: 394.7

CAS: 1227675-51-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Behavioral Neuroscience|Food Intake

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