A K+-competitive inhibitor of H+/K+-ATPases that is best known for its ability to block acid secretion through its action against the gastric H+/K+-ATPase (IC50 = 1.3 µM); effective against gastric H+/K+-ATPases from a variety of species and can inhibit some colonic H+/K+-ATPases

SCH 28080 – 5 mg

Brand:
Cayman
CAS:
76081-98-6
Storage:
-20
UN-No:
Non-Hazardous - /

SCH 28080 is a reversible K+-competitive inhibitor of H+/K+-ATPases that is best known for its ability to block acid secretion through its action against the gastric H+/K+-ATPase (IC50 = 1.3 µM).{29478,29482,29481} It is effective against gastric H+/K+-ATPases from a variety of species and can inhibit colonic H+/K+-ATPases, but this activity appears to be species-dependent.{29480} SCH 28080 is also used to investigate the role of H+/K+-ATPases in non-mammalian organisms and to distinguish the actions of H+/K+-ATPases from other ATP-dependent transporters.{29477,29479}  

 

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Description

A K+-competitive inhibitor of H+/K+-ATPases that is best known for its ability to block acid secretion through its action against the gastric H+/K+-ATPase (IC50 = 1.3 µM); effective against gastric H+/K+-ATPases from a variety of species and can inhibit some colonic H+/K+-ATPases

Formal name: 2-methyl-8-(phenylmethoxy)-imidazo[1,2-a]pyridine-3-acetonitrile

Synonyms: 

Molecular weight: 277.3

CAS: 76081-98-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area

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