A gp130 inhibitor; inhibits phosphorylation of STAT1

SC144 (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
917497-70-2
Storage:
-20
UN-No:
Non-Hazardous - /

SC144 is an orally bioavailable gp130 inhibitor.{46760} It inhibits phosphorylation of STAT1, STAT3, and Akt induced by leukemia inhibitory factor (LIF) and IL-6, but not IFN-γ, in OVCAR-8 ovarian cancer cells when used at a concentration of 20 µM. SC144 induces cell cycle arrest at the G0/G1 phase in MDA-MB-435 breast and HT-29 colorectal cancer cells and inhibits proliferation of 14 cancer cell lines, including prostate, ovarian, lung, breast, and colorectal cancer cells, with IC50 values ranging from 0.4 to 4 µM.{46761} It reduces tumor growth in OVCAR-8 and MDA-MB-435 mouse xenograft models.{46760,46761}  

 

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SKU: 29714 - 25 mg Category:

Description

A gp130 inhibitor; inhibits phosphorylation of STAT1, STAT3, and Akt induced by LIF and IL-6, but not IFN-γ, in OVCAR-8 ovarian cancer cells at 20 µM; induces cycle arrest at the G0/G1 phase in MDA-MB-435 breast and HT-29 colorectal cancer cells and inhibits proliferation of 14 cancer cell lines (IC50s = 0.4-4 µM); reduces tumor growth in OVCAR-8 and MDA-MB-435 mouse xenograft models

Formal name: 2-pyrazinecarboxylic acid, 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide, monohydrochloride

Synonyms: 

Molecular weight: 358.8

CAS: 917497-70-2

Purity: ≥98%

Formulation: A crystalline solid

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