An activator of Akt that blocks its membrane translocation while allowing its phosphorylation

SC-79 – 25 mg

Brand:
Cayman
CAS:
305834-79-1
Storage:
-20
UN-No:
Non-Hazardous - /

SC-79 is an activator of Akt that blocks its membrane translocation while allowing its phosphorylation, in the cytosol, by upstream kinases.{31840} For example, both Thr308 and Ser473 on Akt are phosphorylated in serum starved HeLa cells treated for 1 hour with insulin growth factor and SC-79 (4 µg/ml).{31840} SC-79 permits phosphorylation and activation of all isoforms of Akt, it is active in multiple cell types, and works in both receptor tyrosine kinase- and G protein-coupled receptor-mediated signaling.{31840} SC-79 has been used to elucidate the role of Akt signaling in neuronal survival, glucose-mediated apoptosis in podocytes, and miR-221-regulated cancer cell proliferation.{31841,31840,31842}  

 

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Description

An activator of Akt that blocks its membrane translocation while allowing its phosphorylation, in the cytosol, by upstream kinases; permits phosphorylation and activation of all isoforms of Akt in multiple cell types

Formal name: 2-amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid, ethyl ester

Synonyms: 

Molecular weight: 364.8

CAS: 305834-79-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Neuroscience

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