An inhibitor of NF-κB (EC50 = 0.1 μM in an NF-κB reporter gene assay); inhibits replication of human

SC-75741 – 25 mg

Brand:
Cayman
CAS:
913822-46-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

SC-75741 is an inhibitor of NF-κB (EC50 = 0.1 μM in an NF-κB reporter gene assay).{39637} It inhibits replication of human, avian, and swine influenza virus strains in MDCK cells in a concentration-dependent manner.{39638} It also reversibly inhibits replication of H5N1 and H7N7 avian influenza virus strains in human A549 cells. In vivo, SC-75741 (15 mg/kg, i.p.) reduces viral mRNA and production of IL-6 and CXCL10/IP-10 in the lungs of H5N1 infected mice. SC-75741 is also protective against H5N1 and H7N7 infection in mice when administered for 7 days prior to or up to 4 days post infection.{39639}  

 

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Description

An inhibitor of NF-κB (EC50 = 0.1 μM in an NF-κB reporter gene assay); inhibits replication of human, avian, and swine influenza virus strains in MDCK cells in a concentration-dependent manner; reversibly inhibits replication of H5N1 and H7N7 avian influenza virus strains in human A549 cells; reduces viral mRNA and production of IL-6 and CXCL10/IP-10 in the lungs of H5N1 infected mice (15 mg/kg, i.p.); protective against H5N1 and H7N7 infection in mice when administered for 7 days prior to or up to 4 days post infection

Formal name: N-(6-benzoyl-1H-benzimidazol-2-yl)-2-(1-thieno[3,2-d]pyrimidin-4-yl-4-piperidinyl)-4-thiazolecarboxamide

Synonyms: 

Molecular weight: 565.7

CAS: 913822-46-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Influenza

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