An allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt; inhibits Akt activity in HEK293T cells

SC-66 – 25 mg

Brand:
Cayman
CAS:
871361-88-5
Storage:
-20
UN-No:
Non-Hazardous - /

Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-associated phosphatidylinositol-3,4,5-trisphosphate (PIP3) or phosphatidylinositol-3,4-bisphosphate (PIP2).{13740} Increased Akt activity, e.g., through a gain-of-function mutation in the PHD of Akt1, is pivotal to many types of cancer.{15097} Activated Akt may be regulated by various events, including ubiquitination-mediated deactivation. SC-66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt.{19437} At 4 μg/ml, SC-66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-of-function pleckstrin homology domain mutation, promoting cell death.{19437} In nude mice inoculated with HEK293T cells, SC-66 (15 mg/kg) suppresses tumor growth.{19437}  

 

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SKU: 10876 - 25 mg Category:

Description

An allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt; inhibits Akt activity in HEK293T cells, promoting cell death; suppresses tumor growth in mice

Formal name: 2E,6E-bis(4-pyridinylmethylene)-cyclohexanone

Synonyms: 

Molecular weight: 276.3

CAS: 871361-88-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKB/Akt||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Cell Death||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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