SC-58125 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK 966 (rofecoxib)

SC-58125 – 10 mg

Brand:
Cayman
CAS:
162054-19-5
Storage:
-20
UN-No:
Non-Hazardous - /

SC-58125 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK 966 (rofecoxib), DUP-697, and celecoxib. SC-58125 is a potent and time-dependent inhibitor of COX-2.{1299} When tested on the isolated recombinant enzymes, SC-58125 is at least 150 times more potent in the inhibition of COX-2 as COX-1.{3464} In cultured HUVEC cells, SC-58125 inhibits COX-2 with an IC50 of 70 nM.{5498} It also inhibits the growth of the COX-2 expressing cell line HCA-7 in nude mice at 5-10 mg/kg when given intraperitoneally.{6465}  

 

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SKU: 70655 - 10 mg Category:

Description

SC-58125 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK 966 (rofecoxib), DUP-697, and celecoxib. SC-58125 is a potent and time-dependent inhibitor of COX-2.{1299} When tested on the isolated recombinant enzymes, SC-58125 is at least 150 times more potent in the inhibition of COX-2 as COX-1.{3464} In cultured HUVEC cells, SC-58125 inhibits COX-2 with an IC50 value of 70 nM.{5498} It also inhibits the growth of the COX-2 expressing cell line HCA-7 in nude mice at 5-10 mg/kg when given intraperitoneally.{6465}

Formal name: 5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole

Synonyms: 

Molecular weight: 384.3

CAS: 162054-19-5

Purity: ≥98%

Formulation: A crystalline solid

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