A potent

SC-57461A – 1 mg

Brand:
Cayman
CAS:
423169-68-0
Storage:
-20
UN-No:
Non-Hazardous - /

Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 (Item No. 20110) from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro.{12673,20329} SC-57461A is a potent, orally active inhibitor of LTA4 hydrolase that blocks ionophore-stimulated LTB4 synthesis in whole blood (IC50 = 49 nM).{31025,31023} It blocks both the hydrolase and aminopeptidase activity in vitro.{31023} SC-57461A is without effect against other enzymes of the arachidonic acid cascade, including 5-lipoxygenase, LTC4 synthase, COX-1, and COX-2. In a rat model of ionophore-induced peritoneal eicosanoid production, SC-57461A inhibits LTB4 biosynthesis without affecting LTC4 (Item No. 20210) or 6-keto prostaglandin F1α production (Item No. 15210).{31024} Oral or topical pretreatment with SC-57461A before challenge with arachidonic acid blocks ear edema in mice.{31024}  

 

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SKU: 10108 - 1 mg Category:

Description

A potent, orally active inhibitor of LTA4 hydrolase that blocks ionophore-stimulated LTB4 synthesis in whole blood (IC50 = 49 nM); inhibits LTB4 biosynthesis without affecting LTC4 or 6-keto PGF1α production in a rat model of ionophore-induced peritoneal eicosanoid production

Formal name: N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alanine, monohydrochloride

Synonyms: 

Molecular weight: 363.9

CAS: 423169-68-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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